Map Liver Microstructure in Metabolic Dysfunction-Associated Disease

• Research type

  Research Study

• Full title

  Integrating Synchrotron Tomography with Spatial Omics to Map Liver Microstructure in Metabolic Dysfunction-Associated Liver Disease

• IRAS ID

  368458

• Contact name

  Lorenzo Massimi

• Sponsor organisation

  Italian National Research Council - Nanotec

• Duration of Study in the UK

  0 years, 0 months, 5 days

• Research summary

  Metabolic dysfunction-associated liver disease (MASLD) affects 30% of the global population, progressing from steatosis to hepatocellular carcinoma through complex structural and vascular changes that are poorly understood in three dimensions. We propose to integrate X-ray phase-contrast imaging with spatial omics data to characterize tissue microarchitecture and vascular networks across the complete MASLD spectrum, correlating structural changes with molecular signatures.

• REC name

  London - Brighton & Sussex Research Ethics Committee

• REC reference

  26/PR/0874

• Date of REC Opinion

  8 Jul 2026

• REC opinion

  Favourable Opinion