Manchester Brain Bank

• Research type

  Research Tissue Bank

• IRAS ID

  350689

• Research summary

  Manchester Brain Bank

• REC name

  North East - Newcastle & North Tyneside 1 Research Ethics Committee

• REC reference

  24/NE/0201

• Date of REC Opinion

  5 Dec 2024

• REC opinion

  Further Information Favourable Opinion

• Data collection arrangements

  Samples to be stored include:
  • Post-mortem brain, spinal cord (including dorsal root ganglia where clinically relevant), associated glands and meninges.
  • Post-mortem cerebrospinal fluid
  • Blood product samples (plasma, serum, white cell pellet, DNA etc.)

  Post-mortem CNS tissue samples and CSF will be collected with full informed consent (or via a consultee) from:

  • clinically well-characterised donors suffering from a range of dementias, neurodegenerative and vascular disorders and occasionally related psychiatric or genetic disorders largely collected via prospective clinical studies (e.g. BDR).
  • volunteer normal control donors largely with clinical assessment during life
  • clinically well-characterised donors who suffer from neurological conditions such as stroke, epilepsy, traumatic brain injury and brain tumours.

  Tissue will be preserved by both fixing and freezing techniques

  Blood product samples will be preserved by freezing. These samples have been sourced from various studies including the BDR (BDR) initiative, The Molecular Genetics of Dementias and other Neurodegenerative Disorders, Investigating healthy brain ageing with multiple biomarkers in cognitively normal advanced elderly participants and University of Manchester Longitudinal Study of Cognitive Changes in Normal Healthy Old Age.

  Samples stored within the MBB are located within the Clinical Sciences Building at Salford Royal Hospital with some blood product samples to be stored at the Stopford Building and A.V. Hill Building at the University of Manchester premises on Oxford Road.
  

• Research programme

  MBB is an open access tissue bank supplying tissue for projects into the functioning of the brain and nervous system. Potential donors with brain disorders and normal controls are recruited mainly through clinical research programmes. Samples are supplied for work including molecular and biochemical studies and genetics. Diseases studied will include dementias, cerebrovascular disease, neurodegenerative diseases, some psychiatric disorders, stroke, epilepsy, traumatic brain injury and some brain tumours. Tissue donated to MBB underpins research locally, nationally and internationally. Samples are provided to any applicants who can demonstrate that their project is scientifically and ethically valid.

• Storage license

  12172

• RTBTitle

  Manchester Brain Bank

• Establishment organisation

  The University of Manchester

• Establishment organisation address

  Oxford Road

  Manchester

  M13 9PL