Managing Adolescent first episode Psychosis: a feasibility Study
Research type
Research Study
Full title
Managing Adolescent first episode Psychosis: a feasibility Study (MAPS)
IRAS ID
209020
Contact name
Anthony Morrison
Contact email
Sponsor organisation
Greater Manchester Mental health NHS Foundation Trust
Duration of Study in the UK
1 years, 11 months, 28 days
Research summary
Our primary aim is to determine whether it is feasible to conduct a study to examine the effectiveness of a psychological intervention(Cognitive Behaviour Therapy plus family intervention), antipsychotic medication or a combination of both, in adolescents with first episode psychosis. The research question was developed by the National Institute for Health Research (NIHR), Health Technology Assessment Program (HTA) as a commissioned call (HTA 51/13).
The personal and financial cost of psychosis to the individual, their family and friends, and to society is considerable. Psychosis often begins in adolescence yet the evidence for treatment in this age group is almost exclusively limited to short-term trials of antipsychotics (AP). There are concerns that young people may experience more severe side effects from AP and show a reduced treatment response.
In adults it has been recognised that psychological interventions have an important part to play in the treatment of psychosis.We will conduct a feasibility randomised controlled trial to compare standardised psychological intervention (PI) to treatment with antipsychotic medication (AP) medication and a combined treatment (PI+AP) in 90 adolescents with a first episode of psychosis. This will inform the feasibility and design of a future definitive trial.
Participants will be aged 14-18 years, experiencing first episode psychosis. The study will last for 2 years and participants will be involved in the trial for a maximum of 12-months. Participants will be randomly allocated to either:
1) Psychological Intervention, which will include up to 30 sessions of CBT over a 6-month period, plus an extra 6 sessions of family intervention.
2) Antipsychotic medication, which will be chosen from those commonly used in the treatment of adolescents and recommended in the recent NICE guidelines, with choice of individual drug made by the managing psychiatrist.
3) Combination of PI and AP.All participants will be assessed at baseline, 3,6 and 12 months.
REC name
North West - Greater Manchester East Research Ethics Committee
REC reference
16/NW/0893
Date of REC Opinion
6 Feb 2017
REC opinion
Further Information Favourable Opinion