MAMAS II
Research type
Research Study
Full title
Muscle wAsting in Major Abdominal Surgery (MAMAS II Study)
IRAS ID
269768
Contact name
Ben Creagh-Brown
Contact email
Sponsor organisation
Royal Surrey County Hospital
Duration of Study in the UK
1 years, 0 months, 0 days
Research summary
Following major surgery, the functional capacity of patients is affected. This is due to muscle wasting and weakness. Recovery after surgery can take more than a year especially in frail and elderly patients.
We have previously carried out a study (MAMAS study), which showed patients that undergo elective major abdominal surgery for liver/pancreas/gallbladder/bile ducts and women reproductive tract cancer lose 10 % of their muscle size and undergo a similar decrease in muscle strength within a week of surgery. However more frequent measure of muscle size and strength post-surgery is needed to find out the lowest point of muscle loss and weakness and when the recovery starts.
In this study we will enrol 24 patients having elective major abdominal surgery for liver/pancreas/gallbladder/bile ducts and women reproductive tract cancer. We will measure breathing and thigh muscle size using ultrasound scan and carry out hand grip strength and sniff test (to assess breathing muscle strength) before the surgery, day 1 post-surgery, and thereafter on alternate days until hospital discharge and at 6 weeks after the discharge.
In addition, we will also carry out simple physical function tests and questionnaires before and 6 weeks after surgery. Small amount (~45 mg) of abdominal muscle biopsy tissue will be collected during the surgery (optional) and bloods sample at four time points (pre-op, day 1 post-surgery, day 7 post-surgery/hospital discharge and 6 weeks after discharge) during the study participation.
The outcome of this study will allow to design future interventional studies to reduce the muscle loss and weakness post-surgery. This could lead to improve recovery rate following major abdominal surgery, shorter stay in hospital and fewer post-operative complications and readmission.REC name
London - Bloomsbury Research Ethics Committee
REC reference
19/LO/1886
Date of REC Opinion
16 Dec 2019
REC opinion
Favourable Opinion