Maintenance of Organ Function on Perfusion Rigs
Research type
Research Study
Full title
Using ex vivo organ perfusion to investigate cellular function and interactions
IRAS ID
281751
Contact name
Menna Clatworthy
Contact email
Sponsor organisation
Genome Research Ltd.
Duration of Study in the UK
5 years, 11 months, 31 days
Research summary
In this study we aim to perfuse human organs (kidneys, lungs, heart) ex vivo with warm (37ºC), oxygenated perfusate for up to 72 hours. Whilst the organ is perfused we will add different stimuli such as immune complexes or pathogenic molecules into the perfusion circuit to investigate how cells within the organ respond to these stimuli and interact with each other. This will allow us to study cellular responses in an organ in a physiologically relevant setting, whilst maintaining the normal anatomical relationships of cells, and will allow us to address specific questions relevant to organ function and disease. This research has the potential to improve our understanding of a wide range of diseases affecting multiple organs and may ultimately inform on strategies to improve transplant outcome and treat a broad range of diseases.
REC name
Yorkshire & The Humber - Leeds East Research Ethics Committee
REC reference
20/YH/0260
Date of REC Opinion
15 Sep 2020
REC opinion
Further Information Favourable Opinion