Magnetic resonance imaging and renal transplant function and prognosis
Research type
Research Study
Full title
Non contrast magnetic resonance imaging to measure renal transplant perfusion and fibrosis - association with function and prognosis
IRAS ID
162341
Contact name
Rajan Kanitlal Patel
Contact email
Sponsor organisation
NHS Greater Glasgow and Clyde
Duration of Study in the UK
2 years, 0 months, 1 days
Research summary
Transplantation is the treatment of choice for patients with end stage renal disease. Unfortunately renal transplants only last around 10 years, often failing due to a fibrotic process termed chronic allograft nephropathy.
Existing markers of transplant function and damage include blood (serum creatinine)and proteinuria. These are both insensitive, non specific, and give only limited information regarding the prognosis of a kidney transplant, and provide little information as to the cause of any transplant dysfunction. Novel biomarkers are required in order to provide prognostic and diagnostic information to guide changes therapy and to guide patient expectation.
REC name
East Midlands - Leicester Central Research Ethics Committee
REC reference
15/EM/0171
Date of REC Opinion
21 Apr 2015
REC opinion
Further Information Favourable Opinion