MAGnET - Molecular Analysis of Gastric and OEsophageal Cancers STudy
Research type
Research Study
Full title
MAGnET (Molecular Analysis of Gastric and OEsophageal Cancers STudy). A Prospective Translational Tissue Collection in Early and Advanced Gastric and Oesophageal Cancers to Enable Further Disease Characterisation and the Development of Potential Predictive and Prognostic Biomarkers.
IRAS ID
264017
Contact name
GI Trials
Contact email
Sponsor organisation
The Royal Marsden NHS Foundation Trust
Duration of Study in the UK
5 years, 0 months, 1 days
Research summary
The MAGnET study is a prospective tissue collection study which is intended to set up a database of patients treated for either oesophageal cancer or gastric cancer over a 5 year period at The Royal Marsden Hospital. We will collect tumour tissue and biological specimens (such as blood, saliva and stool) as well as relevant clinical data relating to participants' treatment and follow-up. This series will serve as a valuable platform to analyse the expression of several markers of potential interest which could predict response or resistance to treatment as well as prognosis. This will help to understand why the same type of cancer can behave differently in different people and also show varying responses to the same treatment.
Within this study, we also hope to develop tissue models to represent locally advanced and metastatic disease which will support future drug development. We aim to also investigate the microbiome (the bacteria which colonise individuals) of patients diagnosed with oesophageal or gastric cancer. The molecular analysis plans for the study will develop as the study progresses and as new data emerges which will generate new hypotheses to investigate.
REC name
London - Bloomsbury Research Ethics Committee
REC reference
20/LO/0506
Date of REC Opinion
20 May 2020
REC opinion
Further Information Favourable Opinion