Macular structure function in glaucoma

• Research type

  Research Study

• Full title

  Analysis of inner layer macular structure - function relationship with optical coherence tomography and fundus perimetry in glaucoma

• IRAS ID

  235159

• Contact name

  David F. Garway-Heath

• Contact email

  David.Garway-Heath@moorfields.nhs.uk

• Sponsor organisation

  Moorfields Eye Hospital NHS Foundation Trust

• Duration of Study in the UK

  1 years, 0 months, 1 days

• Research summary

  Summary of Research
  Currently, increasing quality of eye imaging with Spectral Domain Optical Coherence Tomography (SD-OCT) has allowed a precise quantification of the neural tissue of the inner retina, the part of the retina mainly affected by glaucoma. This has been exploited in the management of glaucoma patients, but a comprehensive way to relate anatomical changes and measurements of vision (such as Visual Field Testing) is still lacking. In this study, a novel method for the integration of anatomical and vision changes for the central retina (macula) will be developed, specifically analysing possible sources of mismatch between the two measurements. Visual field testing with eye tracking technology (Fundus perimetry) and SD-OCT will be used for functional and structural assessment respectively. A model to relate structure and function in healthy subjects, also accounting for the axial length of the eye (as a surrogate of the eye size) and the age of the subject, will be developed and used to analyse changes in eyes affected by macular damage from glaucoma.

  Summary of Results
  The study showed that fundus tracking during perimetry in glaucoma generally improved the results of perimetric tests. The effect, while statistically significant, was modest for test-retest variability and negligible for structure-function correlations.
  Additional analyses will focus on locations at the edge of glaucomatous defects, where fundus tracking is more likely to have significant impact.

• REC name

  North of Scotland Research Ethics Committee 1

• REC reference

  17/NS/0121

• Date of REC Opinion

  20 Dec 2017

• REC opinion

  Further Information Favourable Opinion