Lung Screen Uptake Trial v1.0
Research type
Research Study
Full title
Randomised controlled trial to test novel invitation methods and materials targeted to increase informed uptake of lung cancer screening in individuals at high risk of lung cancer.
IRAS ID
166426
Contact name
Mamta Ruparel
Contact email
Sponsor organisation
University College London
Duration of Study in the UK
2 years, 2 months, 1 days
Research summary
Randomised controlled trial to test novel invitation methods and materials targeted to increase informed uptake of lung cancer screening in individuals at high risk of lung cancer.
Lung cancer Low (radiation) Dose Computed Tomography (LDCT) screening has been shown to improve mortality due to lung cancer and all causes. The risk-benefit ratio of screening as an intervention is optimised when the high risk group are targeted but multiple studies have shown that uptake is particularly poor in this group. Qualitative research in this area has highlighted some of the possible explanations for this. This has enabled the development of a novel method of approaching this target population.
The main study objective is to test new materials designed to improve uptake in the form of a randomised control trial comparing more conventional materials. The participants invited are therefore being offered a proven effective screening process in the likelihood of the advent of a national screening programme. The study is powered to detect a 7% improvement in uptake.
The study recruitment period is approximately 1 year starting from Summer 2015. Patients recorded as current smokers aged 60-75 will be identified from GP databases and invited for screening. Participants will be eligible for screening if the smoking history and age criteria are confirmed.
The screening will be carried out in the form of a NHS Screening Demonstration Pilot across two hospital sites within London – a Teaching Hospital and a District General Hospital. Those participants who attend and are confirmed as eligible for screening will be screened by a protocol based on current evidence and best practice guidelines.
Secondary outcome measures will include:
• Evaluation of smoking cessation
• Rates and appraisal of protocols of radiological findings
• Cost effectiveness of screening and impact on local services
• Collection of samples to inform research on potential biomarkers for lung cancer
• Psychological burden and informed decision-makingThis research will provide data and highlight the encountered difficulties to enable stringent planning of a national screening programme and be submitted for publication in peer reviewed journals.
REC name
London - Bromley Research Ethics Committee
REC reference
15/LO/1186
Date of REC Opinion
29 Jul 2015
REC opinion
Favourable Opinion