Lung physiology and imaging in ILD
Research type
Research Study
Full title
Assessing disease severity and progression over time in patients with fibrotic lung disease using novel physiology and imaging modalities
IRAS ID
255788
Contact name
Andrew Wilson
Contact email
Sponsor organisation
University oF East Anglia
Duration of Study in the UK
2 years, 0 months, 0 days
Research summary
Pulmonary fibrosis results in progressive scarring of the lungs. The standard tests using by doctors to assess this scarring are difficult to perform. We would like to study two new methods called impulse oscillometry system (IOS) and magnetic resonance elastography to see if they are easier to undertake and useful to monitor people with pulmonary fibrosis
At present monitoring is undertaken with breathing tests (called spirometry) which are difficult to perform because they require a forced or hard breath out. Also this breathing test does not really measure the fibrosis or scarring of the lung. There are alternative tests which may be easier to do and more useful.
This research is being conducted to establish if a different breathing test called impulse oscillometry system (IOS) is better at monitoring patients with lung scarring than spirometry over a 2 year period. We will see if IOS is better at picking up disease progression compared to spirometry. We will also see if this breathing test explains the changes in people feeling about their disease, which we will measure by questionnaires.
In addition this study will also test another compare another measure of assessing the lungs called Magnetic Resonance Elastography (MRE) with the IOS, questionnaire and spirometry in people with health lungs, those with lung scarring, and those with lung scarring plus emphysema.
Hopefully we will find out if our tests are better and can be used by doctors in the hospital clinic
REC name
Yorkshire & The Humber - South Yorkshire Research Ethics Committee
REC reference
19/YH/0029
Date of REC Opinion
30 Apr 2019
REC opinion
Further Information Favourable Opinion