Lung Health in HIV 2

• Research type

  Research Study

• Full title

  Long-term lung health in people living with HIV part 2

• IRAS ID

  307897

• Contact name

  Paul Collini

• Contact email

  p.collini@sheffield.ac.uk

• Sponsor organisation

  Sheffield Teaching Hospital NHS Foundation Trust

• Duration of Study in the UK

  1 years, 6 months, 26 days

• Research summary

  Chronic lung diseases not related to AIDS are more common among people living with HIV (PLWH). Most commonly adults are affected by chronic obstructive pulmonary disease (COPD). In adolescents and young adults from Sub-Saharan Africa diseases who acquired HIV at birth smaller airways lung diseases called ‘bronchiolitis obliterans’ and ‘bronchiectasis’ are often seen. Recently research has shown that lung function declines more rapidly in PLWH. These physiological findings have been in research with predominantly white male adults. How patient reported outcome measures (PROMS) such as breathlessness or impact on daily living change over time have not been studied. Previous research in Sheffield has shown that the rates of both abnormal lung functional and PROMS are different in women and African PLWH. In the UK 29% of PLWH are Black African and 31% are female.
  This research will study how respiratory PROMS and lung function change over time in PLWH by repeating the same PROMS (St George’s Respiratory Questionnaire and EQ-5D-5L) and lung function (spirometry) tests in patients of Sheffield Teaching Hospital 5-6 years following the same measurement during their involvement in a 2016 Lung HIV study. The changes and rates of new diagnosis like COPD will be compared according to sex and ethnicity. A sub-study will also recruit PLWH who have had HIV since birth to look for markers in the blood that are associated with inflammation and lung diseases and also compare the same PROMS and spirometry observations with the PLWH who acquired HIV as adults. Complete adherence to ART and persistently undetectable viral loads are less frequent among paediatric and young adult HIV clinic populations. These issues do not necessarily mean such patients have clinically unstable HIV but are potentially relevant to the pathogenesis of chronic lung disease. Inclusion criteria for this part of the study are tailored accordingly.

• REC name

  HSC REC B

• REC reference

  21/NI/0201

• Date of REC Opinion

  20 Dec 2021

• REC opinion

  Further Information Favourable Opinion