Lung cancer biomarker nested case-control project

• Research type

  Research Study

• Full title

  Biomarker discovery in a nested case-control study using proteomics technologies in lung cancer serum samples from UKCTOCS.

• IRAS ID

  167840

• Contact name

  Usha Menon

• Contact email

  u.menon@ucl.ac.uk

• Sponsor organisation

  University College London

• Duration of Study in the UK

  3 years, 0 months, 0 days

• Research summary

  The aim of this project is to undertake discovery experiments for novel serum biomarkers for the early diagnosis of lung cancer using the pre-diagnosis serum from the UKCTOCS Biobank. The technology used will be proteomics. The samples used from the lung cancer cases will be close to diagnosis and then at intervals up to 10 years prior to diagnosis which will give the project the best chance to identify those markers which are up-regulated early in the course of the disease. Proteomics methods will be used first to determine the relative levels of potential biomarkers in 25 lung cancer cases cases vs 25 controls and the biomarkers discovered will be further analysed in the remaining 100 lung cancer cases and 100 controls.

• REC name

  Yorkshire & The Humber - Sheffield Research Ethics Committee

• REC reference

  15/YH/0044

• Date of REC Opinion

  21 Jan 2015

• REC opinion

  Favourable Opinion