Lumbar Sympathetic Chain (LSC) Stimulation for Nociceptive Pain
Research type
Research Study
Full title
Prospective, Open Label Trial to Assess Tolerability of Lumbar Sympathetic Chain Stimulation in patients with Nociceptive pain due to Knee OsteoArthritis or Endometriosis
IRAS ID
327347
Contact name
Ganesan Baranidharan
Contact email
Sponsor organisation
ABVF BV
ISRCTN Number
ISRCTN65454491
Duration of Study in the UK
1 years, 6 months, 1 days
Research summary
Pain in the knee due to osteoarthritis (OA) and pain in the pelvic area due to endometriosis can have significant impacts on the lives of patients. Treatment options can include medications which can have limited effectiveness. The lumbar sympathetic chain (LSC) is a group of nerves that supply the feet, legs and pelvic area. They are close to the spine in the lower part of the back and play an important role in transferring pain signals to the brain. This group of nerves will be stimulated in this study. \n\nThis pilot study aims to evaluate the safety and tolerability of stimulation of the LSC in patients with knee OA or pelvic pain due to endometriosis.\n\nUp to five patients with knee pain due to knee OA and five patients with pelvic pain due to endometriosis will have insertion of a commercially available stimulation device on the LSC. \n\nTo monitor the safety and tolerability of the LSC stimulation, patients will be followed-up at:\n- Twenty-one days after insertion of the device where the wound will be examined and device will be activated\n- Have a video check-in every week for three weeks\n- Return to the pain clinic for a face-to-face appointment at 30, 60, 90 and 180 days after the device has been activated\n- Have video check-ins at 120 and 150 days after the device has been activated
REC name
North of Scotland Research Ethics Committee 1
REC reference
23/NS/0089
Date of REC Opinion
3 Sep 2023
REC opinion
Favourable Opinion