LUCI Study version 1.0
Research type
Research Study
Full title
LUCI: Long-term follow-up of urinary tract infection (UTI) in childhood and implications: an electronic record-linked cohort study
IRAS ID
188342
Contact name
Kathryn Hughes
Contact email
Duration of Study in the UK
1 years, 11 months, 30 days
Research summary
This project aims to determine outcomes following urine infections (UTI) in childhood and to determine whether there is a difference between UTI identified through routine practice and UTI identified through systematic urine sampling (where all ill children have their urine sampled). \nIt is thought that childhood UTI can lead to scarring of the kidneys which in some cases leads to long-term complications such as high blood pressure, chronic kidney disease and kidney failure. The evidence is weak and has been questioned. There is an urgent need to clarify the association between childhood UTI, kidney scarring and long-term complications as the correct approach to urine sampling and diagnosis of UTI in children hinges on this association. \nUTI is difficult to diagnose in children and we have shown that as many as 80% of UTIs are missed in primary care. A urine sample is required to diagnose UTI but urine is infrequently sampled from ill children in routine primary care (in less than 2% of consultations).\nWe have previously conducted two large studies where urine was systematically sampled from all ill children less than five years old (the DUTY and EURICA studies). Only a sample of these children were followed-up for a short time.\nIn the current study we propose to use routinely collected data to follow-up DUTY and EURICA children for 5 years to determine outcomes for UTI identified through systematic urine sampling (including further UTI, hospital admissions, kidney scarring, high blood pressure and kidney failure). We will also determine outcomes for children (<5 years) presenting with an acute illness, with and without UTI, identified through routine practice. \n
REC name
Wales REC 3
REC reference
16/WA/0166
Date of REC Opinion
10 Jun 2016
REC opinion
Favourable Opinion