Lower Limb FFR Study
Research type
Research Study
Full title
Combining invasive functional testing with anatomical imaging to guide endovascular therapy in peripheral arterial disease.
IRAS ID
239160
Contact name
Mohamad Hamady
Contact email
Sponsor organisation
Imperial College Healthcare NHS Trust
Duration of Study in the UK
2 years, 0 months, 1 days
Research summary
Narrowing of blood vessels in the leg reduces blood flow, which may cause symptoms of pain or gangrene – a condition known as peripheral arterial disease (PAD). Many patients with this condition often have more than one narrowing in the affected vessel. Identifying which narrowing is causing the greatest restriction to blood flow can help doctors decide which ones should be targeted for invasive treatment. For narrowing’s in the heart vessels, this is routinely done by inserting a sensing wire that measures pressure and speed of blood travelling across each narrowing as part of the patient’s standard angioplasty procedure. We currently have no method to obtain these measurements in the leg vessels. The aim of the study is to recruit patients with a narrowing of the peripheral vessel who are already scheduled for lower limb angiogram/angioplasty and take blood pressure and flow measurements across the narrowed segment of their artery.
REC name
West of Scotland REC 5
REC reference
22/WS/0033
Date of REC Opinion
23 Mar 2022
REC opinion
Favourable Opinion