Low exhaled NO and inhaled corticosteroids in suspected asthma
Research type
Research Study
Full title
Does a low exhaled Nitric Oxide level exclude a clinical benefit from inhaled corticosteroids in suspected asthma; a double-blind, randomised, placebo controlled trial.
IRAS ID
185217
Contact name
Tim Harrison
Contact email
Sponsor organisation
University of Nottingham
Eudract number
2016-000338-23
Duration of Study in the UK
1 years, 5 months, 10 days
Research summary
This study aims to examine if a low exhaled nitric oxide level is a good indicator of people who will NOT have a clinical benefit from an inhaled steroid in patients suspected of having asthma (with asthma like symptoms) by their GP or practice nurse.
The study plans to recruit patients who are suspected of having asthma by their GP or practice nurse.
Once consented the patients will be randomised to recieve either a placebo or an inhaled corticosteroid inhaler for 3 months. Participants will be followed up at 4 weeks, 8 weeks and 12 weeks after commencing the trial medication. The participant will be in the study for 3 months.A total of 165 patients aged 16 years and over with suspected asthma will be eligible for inclusion.
To facilitate non biased observations this will be a double-blind study; neither the patients nor the research nurse/doctor will know which group the patient will be assigned to.
REC name
East Midlands - Leicester South Research Ethics Committee
REC reference
16/EM/0073
Date of REC Opinion
21 Mar 2016
REC opinion
Further Information Favourable Opinion