LOST COMPS
Research type
Research Database
IRAS ID
326987
Contact name
Gouri Koduri
Contact email
Research summary
Long term Observational STudy of rheumatic disease COMPlicationS (LOST COMPS): monitoring the incidence and prognosis of cardiac, respiratory, and vascular complications of rheumatic disease
REC name
South Central - Berkshire B Research Ethics Committee
REC reference
24/SC/0183
Date of REC Opinion
23 Jul 2024
REC opinion
Further Information Favourable Opinion
Data collection arrangements
Patients with all rheumatic conditions will be followed for a minimum of 5 years. Routine data will be collected by the research at baseline and at follow up visits(3, 6 months and at annual follow up).
Data, which is collected by the research team, at the time of the routine clinic visit will be stored on Redcap, which is a secure web database for NHS organisationResearch programme
This study is a non-interventional, multicentre, longitudinal, prospective study on Rheumatic conditions. The two most common causes of death are Interstitial Lung Disease (ILD) and cardiovascular complications. Patients with rheumatic conditions have higher incidence of Cardiovascular events as compared to general population. The consequence of delayed treatment is significant, leading to disability, decreased quality of life, comorbidities, and mortality. It is important that we need to understand and to think about which of our patients are at the highest risk, and to identify those who have early or progressive ILD and cardiac complications and to consider established and newer treatment options for ILD and other complications. To achieve this important goal, a study of a large RA and CTD cohorts with detailed clinical phenotyping and longitudinal follow- up is required. Patients with all rheumatic conditions will be followed for a minimum of 5 years. The research findings will be presented at the conferences, websites and published in a peer reviewed d journal. This study will help to investigate the burden of the complication, identify the risk factors for the development of clinical prediction models, common trajectories of distinct clinical patterns in a large cohort, long term effectiveness of disease modifying drugs and antifibrotics. It will help us to develop protocols for screening, monitoring and treatment. It will assist us to develop cost effective models and design services for people with comorbidities. This information can be used by policy makers or practitioners to make informed decisions about interventions, programs and policies.
Research database title
Long term Observational STudy of rheumatic disease COMPlicationS (LOST COMPS): monitoring the incidence and prognosis of cardiac, respiratory, and vascular complications of rheumatic disease
Establishment organisation
Southend University hospital,Mid and South Eessex NHS Trust
Establishment organisation address
Prittlewell chase
Westcliff onsea
Essex
SS0 0RY