Long Term proctocolectomy outcomes in FAP patients
Research type
Research Study
Full title
Long term outcomes after (procto)colectomy in patients with familial adenomatous polyposis: an international multi-centre cohort study
IRAS ID
311398
Contact name
Andrew Latchford
Contact email
Sponsor organisation
London North West University Hospitals Trust
Duration of Study in the UK
1 years, 0 months, 1 days
Research summary
Large bowel surgery is required in virtually all patients with FAP to prevent colorectal cancer. Deciding what type of operation is a key decision. A group of experts, who clinically manage this rare condition have met to establish a European FAP Consortium, with the aim to collaborate in sharing of clinical data for highlighted areas of need in the management of FAP, so as to inform clinical management.
1. Some of the data used to inform such decision making and outcome data from different types of surgery are historical. There have been advances in endoscopy technology and therapeutic abilities which are not considered in these old data. This specifically may influence risk of cancer development or need for repeat surgery. This study will better assess outcomes in the modern era, which may guide better surgical decision making.
2. Desmoid formation may be induced by surgery. This risk may vary by type of operation and indeed the approach to an individual operation (eg “open” or “laparoscopic”). Better understanding of desmoid risk according to each operative approach will help guide surgery decision making, particularly in those individuals are more predisposed to desmoid.
3. From a patient perspective day to day quality of life is extremely important. This may vary significantly according to type of surgery. Data related to this are old and usually single centre. These data do not take in to account advances in surgical technique with time. Better understanding of functional outcomes of surgery will be important in terms of surgical decision making but also patient counselling prior to any surgical intervention.REC name
London - Westminster Research Ethics Committee
REC reference
22/PR/0073
Date of REC Opinion
1 Aug 2022
REC opinion
Further Information Favourable Opinion