Long-term outcomes in women diagnosed with non-invasive breast cancer
Research type
Research Study
Full title
Population based study of outcomes and long-term trends in women diagnosed with non-invasive breast cancer
IRAS ID
192243
Contact name
Gurdeep S. Mannu
Contact email
Sponsor organisation
University of Oxford
Duration of Study in the UK
1 years, 0 months, 19 days
Research summary
Ductal carcinoma-in-situ (DCIS) is the most common type of non-invasive breast cancer. There is little information available on long-term prognosis for women diagnosed with non-invasive breast cancer. Critical examination of long-term data, such as that held by Public Health England (PHE) and the National Health Service Breast Screening Programme (NHSBSP) audit, would provide valuable insights into the prognosis of women with DCIS and other types of invasive breast cancer.
This study will examine long-term outcomes in women diagnosed with DCIS or other types of non-invasive breast cancer on a population level and the way that these outcomes have changed over time. It will examine the risks of developing invasive breast cancer and of dying from breast cancer and other causes, and the factors that determine these risks. It will also compare mortality rates in women diagnosed with non-invasive breast cancer with those of women diagnosed with invasive breast cancer, and with women in the general population. Such a study has not previously been conducted in the UK. The results from this study will have important implications for our understanding of the burden of disease from DCIS and other types on non-invasive breast cancer. They may also help to shed new light on the accepted theories of pathophysiology and underlying biology of these conditions. Please see section A10 for objectives and please see section A13 for methodology information.
REC name
Yorkshire & The Humber - Leeds East Research Ethics Committee
REC reference
16/YH/0209
Date of REC Opinion
18 May 2016
REC opinion
Favourable Opinion