Long term outcomes in patients treated for oesophageal atresia.
Research type
Research Study
Full title
Long term outcomes in patients treated for oesophageal atresia (primary repair vs gastric transposition).
IRAS ID
180957
Contact name
Emma Pendleton
Contact email
Sponsor organisation
UCL Institute Of Child Health
Duration of Study in the UK
1 years, 6 months, days
Research summary
Oesophageal atresia is a rare condition in which a baby's oesophagus is not formed properly at birth. It is usually repaired soon after birth by joining the 2 unconnected ends together (primary repair). In some cases where most of the oesophagus is missing patients require the stomach to be brought into the chest to replace the missing oesophagus (gastric transposition) later in childhood.
Evidence of the long term outcomes in these patients is limited as they progress from children's services into adult services getting lost to the follow up of the paediatric surgeon. There is specific concern about the long term risk of Barretts oesophagus (a precancerous condition) which limited studies suggest is higher in oesophageal atresia patients.The aims of this study are to assess the long term outcomes of oesophageal atresia including those treated with primary repair and gastric transposition. Outcomes include current health status, complications from the condition or the surgery, incidence of Barretts oesophagus and cancers and health related quality of life.
Methods
Stage 1a: HES data request to establish incidence of oesophageal atresia and current practice.
Stage 1b: From pre-existing Great Ormond Street Hospital databases 2 groups of oesophageal atresia patients will be identified, those treated with primary repair and those with gastric transposition and are at least 18 years old. We will track their clinical outcomes by applying for Hospital Episode Statistics (HES) data (centrally held data on NHS hospital attendance).Stage 2: Using identifiers from HES - we will directly contact a pilot group of 20 patients from each group to get more detailed information of their long term follow up. This will involve a structured telephone interview and 2 validated questionnaires covering patient history, health status and quality of life.
Stage3: Following review stage 1 & 2 we will consider enrolling all patients from Stage 1 into stage 2.
REC name
London - Westminster Research Ethics Committee
REC reference
15/LO/1325
Date of REC Opinion
19 Oct 2015
REC opinion
Further Information Favourable Opinion