Long-Term Outcomes in Meningioma (LTOM)
Research type
Research Study
Full title
Long-term outcomes following meningioma surgery
IRAS ID
295443
Contact name
Adel Helmy
Contact email
Sponsor organisation
Cambridge University Hospital NHS Foundation Trust and the University of Cambridge (joint sponsors)
Duration of Study in the UK
14 years, 11 months, 31 days
Research summary
Meningiomas are one of the most common intracranial tumours, accounting for around a third of all primary brain tumours. The tumours are histologically and genetically classified according to the CNS WHO classification system, which includes grades 1, 2, and 3. Depending on the tumour size and location, treatment options are surgical resection, radiotherapy, or adjuvant radiotherapy following tumour resection. Clinical outcomes and survival rates depend on tumour grade and extent of resection, though further tumour and patient characteristics may also be important prognostic factors.
While data is available for the 5-year and 10-year survival rates, survival beyond this is largely unknown due to the lack of patient follow-up data, and few studies have looked at the long-term impact on quality of life in meningioma survivors. This study will examine the impact of meningiomas beyond the typical follow-up period in patients who underwent meningioma surgery at Addenbrooke’s hospital between the years 2000 and 2024. Associations between presenting clinical features, location of meningioma, meningioma histology and long-term outcomes will be investigated, and we hypothesise long-term hidden disability in our population as a result of the meningioma compared to the general population. Data on patient and clinical characteristics will be collected from patient records using existing databases and patients will be contacted to collect follow-up data on quality of life, and meningioma-related disabilities.
Understanding the long-term outcomes of meningiomas is important for treatment decisions and better informing patients of the true impact of their diagnosis. With the increasing focus on a patient-centric care, it is important to understand the long-term effects to improve follow-up care and patient satisfaction, as well as better aid patient and caregiver expectations. Addenbrooke’s Hospital, a major neurosurgical centre, has the resources and patient numbers to conduct such a study to improve the overall understanding of meningioma outcomes.
REC name
West of Scotland REC 3
REC reference
25/WS/0068
Date of REC Opinion
12 Aug 2025
REC opinion
Further Information Favourable Opinion