Long term follow up of ASCOT trial into Electronic Records (LATER)

• Research type

  Research Study

• Full title

  Long term follow up of the ASCO Trial into Electronic Records (LATER)

• IRAS ID

  178835

• Contact name

  Peter Sever

• Sponsor organisation

  Imperial College London

• Clinicaltrials.gov Identifier

  08/H0712/135, BEST-ASCOT

• Duration of Study in the UK

  4 years, 0 months, 14 days

• Research summary

  Large studies have shown that people with higher blood pressure and higher cholesterol in mid-life have a higher risk of dementia and other illnesses in later life. However, there is little support from randomised trials or genetic studies that lowering midlife blood pressure, or prescribing statins prevent dementia, or have a legacy effect in the reduction in the risk of heart attack or stroke. Therefore more data is needed in order to support public health interventions to prevent dementia.

  Dementia is an insidious condition, and probably develops over many years. Very long term trials may not be feasible, would be extremely expensive, and would take many years before they could have an impact on public health. In order to lengthen the follow up period of existing trials, we propose to follow up UK participants in ASCOT by using information in the electronic health records of the UK national health systems and to measure the development of dementia over the very long term.

• REC name

  South East Scotland REC 01

• REC reference

  18/SS/0016

• Date of REC Opinion

  19 Feb 2018

• REC opinion

  Favourable Opinion