Long Bone Diaphyseal Adaptation to Lifetime Loading v.1
Research type
Research Study
Full title
Long Bone Diaphyseal Adaptation to Lifetime Loading
IRAS ID
165362
Contact name
Jay Stock
Contact email
Sponsor organisation
University of Cambridge
Duration of Study in the UK
5 years, 0 months, 1 days
Research summary
Cross-sectional geometric properties (total area, cortical area, shape, estimated torsion and bending strength) will be measured at the hand (first metacarpal) forearm (radius, ulna), upper arm (humerus), foot (first and fifth metatarsal) lower leg (tibia, fibula) and upper leg (femur) (pQCT) in athletes and sedentary controls to investigate the influence of activity history (questionnaire) on musculoskeletal morphology (bone, muscle, adipose tissue). Measurements will be taken on 910 participants (70 low intensity-low frequency habitual loaders (i.e. sedentary controls), 280 low intensity-high frequency loaders (i.e. race walkers), 280 low frequency-high intensity loaders (i.e. sprinters) and, finally, 280 high frequency-high intensity loaders (i.e. rugby players)) aged 19 to 45 years. On the day that scanning is to take place athletic history questionnaires will be completed by each participant, and will be followed by pQCT scans taken on the right and left hand (at 50% of segment length), forearm (4%, 50%, 65%), upper arm (35%, 50%), foot (50%), shank (4%, 50%, 65%) and the upper leg (4%, 50%). The scans are non−invasive, simple to perform and require the participant to sit on a chair during measurements. The height, weight, limb segment length, hip breadth (Morphometric Measurements Sheet), and date of birth of each participant will be recorded. The total time required to complete the Activity History questionnaire and consent form is 30 minutes, while pQCT scans require ~2.0 hours. Therefore, all measurements will be completed within approximately 2.5 hours.
REC name
East of England - Cambridge East Research Ethics Committee
REC reference
15/EE/0017
Date of REC Opinion
8 May 2015
REC opinion
Further Information Favourable Opinion