LOLIPOP 100K study
Research type
Research Study
Full title
Investigation of lifestyle, environmental, genomic and molecular factors underlying health outcomes in South Asians and Europeans – the LOLIPOP 100K study
IRAS ID
248261
Contact name
Jaspal Kooner
Contact email
Sponsor organisation
Imperial College London
Duration of Study in the UK
20 years, 0 months, 0 days
Research summary
South Asians living in the UK are at high risk of both cardiovascular disease (CVD) and type-2 diabetes (T2D). The mechanisms are not known. To advance understanding of metabolic, cardiovascular and other important chronic diseases in UK South Asians, we propose to establish LOLIPOP 100K, a longitudinal population study comprising ~100,000 South Asian and European men and women, aged 25-85 years, under long-term follow-up for health outcomes. All participants will complete a structured assessment comprising: i. Registration and consent; ii. Questionnaires (health and lifestyle, cognition and dietary intake); iii. Physical measurements (height, weight, waist, hip, bioimpedance, blood pressure, electrocardiogram, lung function and retinal photograph); iv. Biological samples (blood, urine and stool) and v. Physical activity monitoring. The assessment is expected to take around 90 minutes. Blood samples will be stored at -80°C.
All participants will be followed-up for their health long term through medical and other health-related records. This will include linkage for; i. death; ii. site-specific cancer, iii. Hospital Episode Statistics (HES) for England and Wales; Scottish Morbidity Record (SMR) for Scotland; iv. myocardial infarction (MINAP), stroke (SINAP); v. pathology services; vi. hospital databases ; vii. primary-care health records.
Data and samples will be used to investigate the behavioural, environmental, genetic and other molecular factors influencing health and disease in South Asian populations.
REC name
London - Fulham Research Ethics Committee
REC reference
20/PR/0553
Date of REC Opinion
7 Jan 2021
REC opinion
Further Information Favourable Opinion