LOFT-MRI: Optimising Low-Field MRI in Healthy Volunteers V1
Research type
Research Study
Full title
LOFT-MRI: Low-field Optimisation of Functional imaging Technologies in MRI: Development and validation of RF coils, imaging sequences, and post-processing methods for low-field MRI in healthy volunteers
IRAS ID
356236
Contact name
James M Wild
Contact email
Sponsor organisation
University of Sheffield
Duration of Study in the UK
3 years, 8 months, 1 days
Research summary
This study will explore new ways to improve low-field MRI scanning using a 0.5 Tesla scanner, which operates at a lower magnetic strength than most hospital scanners. We aim to develop and test better imaging methods and technologies so that clear, high-quality images can still be obtained at this lower strength. This includes both standard MRI that looks at the body's water and fat (called proton MRI), and more advanced types that use special gases like xenon-129 to study how the lungs and other organs work. We will design and test new radiofrequency (RF) coils specifically for use with the low-field 0.5T MRI system. These coils are essential components that allow the scanner to transmit and receive signals from the body. The aim is to optimise performance and image quality at this lower magnetic field strength. Custom software is being developed to control how the MRI data is collected and turned into images. This includes adjustments to scanning procedures and image processing tailored for the 0.5T system. All software development follows established protocols from GE Healthcare and the University of Sheffield, in line with previous studies. The study will include measuring specific values from the MRI scans (e.g. signal intensity, tissue characteristics) to understand what is considered normal at 0.5T. Establishing these reference values will help ensure that future clinical and research scans at this field strength can be reliably interpreted. When a new scanner, radiofrequency (RF) coil or image sequence is introduced, it must be tested to ensure it meets technical and safety standards. This involves scanning healthy volunteers using different sequences across body regions to confirm that the system is working as intended and is fit for purpose. We are conducting this research to evaluate the performance of the MRI system and associated components that will be developed.
REC name
London - Stanmore Research Ethics Committee
REC reference
25/LO/0497
Date of REC Opinion
5 Aug 2025
REC opinion
Further Information Favourable Opinion