LOCATE Version 1
Research type
Research Study
Full title
LOCATE:Localising Occult prostate Cancer metastases with Advanced imaging TEchniques (LOCATE)
IRAS ID
148693
Contact name
Shonit Punwani
Contact email
Duration of Study in the UK
3 years, 0 months, 1 days
Research summary
Advanced MRI techniques that allow us to visualise disease within the whole-body may provide a better method for detection of disease spread from prostate cancer as compared to current imaging methods. We know that current imaging methods (computed tomograph and bone-scan) are not very good at detecting early disease spread. We are proposing to conduct a study where patients get both sets of imaging in order to prove that multi-parametric whole-body MRI is a better test. We would like to perform the comparison in the group of men who have previously been confirmed to have prostate cancer and have undergone local treatment (either with external radiation or with radioactive seeds placed within the prostate). We know that almost half the men within this group will have disease recur at 5 years from therapy based on high levels of the blood test 'PSA'. In many cases the site of recurrent disease is not found by standard imaging. We expect that advanced MRI techniques maybe better able to pick up this recurrent disease.
REC name
London - Chelsea Research Ethics Committee
REC reference
15/LO/0776
Date of REC Opinion
19 Jun 2015
REC opinion
Further Information Favourable Opinion