LITMUS: Linking Thrombosis to Metabolic Status in Diabetes Mellitus
Research type
Research Study
Full title
LITMUS: Linking Thrombosis to Metabolic Status in Diabetes Mellitus
IRAS ID
270163
Contact name
Tim Palmer
Contact email
Sponsor organisation
University of Hull
Duration of Study in the UK
10 years, 0 months, 0 days
Research summary
Approximately 80% of people with diabetes will die of cardiovascular disease (CVD), including heart attacks and strokes. These occur when small cells in the blood called platelets aggregate at sites of blood vessel damage to form blood clots, which interrupt blood flow and cause tissue damage. However, while high blood glucose can predict susceptibility to CVDs, mechanisms linking high blood glucose with increased platelet aggregation are unknown. We believe high blood glucose levels increase platelet stickiness by a post-translational modifications including “O-GlcNAcylation”. By changing the function of important platelet proteins, these modifications increase the risk of heart attack and stroke in people with diabetes. Our research aims to identify new proteins modified in platelets in diabetes. By discovering new mechanisms linking high blood glucose with CVD, we may identify targets for new medicines to reduce the risk of heart attack and stroke in people with diabetes
REC name
London - Brighton & Sussex Research Ethics Committee
REC reference
22/PR/0945
Date of REC Opinion
28 Jul 2022
REC opinion
Further Information Favourable Opinion