LITE Study – Light Emitting Diode in Endoscopic Tissue Evaluation
Research type
Research Study
Full title
Prospective feasibility study of LED light in minimally invasive intra-abdominal and fluorescence cystoscopy tissue evaluation.
IRAS ID
190734
Contact name
Daniel Elson
Contact email
Sponsor organisation
Imperial College London
Duration of Study in the UK
1 years, 0 months, 1 days
Research summary
The aim of this study is to elucidate the feasibility of using a multi-coloured LED (light emitting diode) light source in endoscopy as an alternative to the standard Xenon white light. The LED light is a safe (working below known power safety limits) and reliable light source that has a number of advantages over the xenon lamp, including the control of the white light colour balance, as well as usability and cost improvements. We hope to demonstrate a comparable performance between xenon and LED light sources in a test procedure involving the visualisation of intraabdominal cancer spread from primary cancers involving the gullet (oesophagus) or stomach (gastric).\n\nDuring the course of determining the surgical operability of these primary cancers (cancer staging), a preliminary surgical procedure is performed primarily to establish if there is any spread of cancer within the abdomen. During this procedure the xenon lamp and LED lamp will be compared by acquiring images with the standard endoscopic camera and changing the light source into which the light cable is connected.\n\nIn addition, subtle deposits of cancer within the abdomen are occasionally missed by the naked eye using standard white light used. We will investigate whether adjustments to the red, blue, and green light wavelengths can help to better identify these lesions. This could theoretically improve detection of cancer spread without in any way compromising the surgery being performed. If it can be shown that the LED light source provides equivalent visualisation when compared with the xenon source, then the LED lamp could potentially be used in many types of other endoscopic procedures. At this stage these images will not be presented to the surgeon during the operation itself, and the current technology will be used for all clinical decision making.\n
REC name
London - Bloomsbury Research Ethics Committee
REC reference
18/LO/0389
Date of REC Opinion
19 Mar 2018
REC opinion
Favourable Opinion