Lipid variability in diabetes Version 2- 24.06.2014
Research type
Research Study
Full title
Effect of acute fluctuations of hyperlipidaemia on insulin resistance and cardiovascular risk in patients with type 2 diabetes
IRAS ID
154259
Contact name
Thozhukat Sathyapalan
Contact email
Sponsor organisation
Hull and East Yorkshire Research and Development Department
Clinicaltrials.gov Identifier
, NA
Research summary
Patients with diabetes can have high level of lipid (fat) in their blood. Both high blood glucose (sugar) and high fat (lipid) levels increase the risk of cardiovascular disease such as angina, heart attack, stroke and hypertension in patients with diabetes. In fact, the blood glucose and fat levels vary with timing of our food intake. For example, blood glucose and fat levels are high in our blood for a few hours after the meals and then the levels gradually fall towards the next meal. Previous research studies showed that fluctuation and excessive rise in glucose level following a meal increase the complications of diabetes and cardiovascular risk. However the effect of acute fluctuation of lipid levels on insulin secretion and risk of cardiovascular disease is unknown.
This study aimed to investigate the effect of fluctuation in lipid level on risk of cardiovascular disease in diabetes participants in comparing with healthy volunteers.
The information received from the study will help us to understand why diabetes patients are increased risk of cardiovascular disease and to find a way to improve this in the future.
This is a pilot non-randomised non-CTIMP study.
This study will recruit 16 participants with type 2 diabetes and 16 age and body mass index (BMI) matched healthy controls. Participants with type 2 diabetes will be recruited using the diabetes research register and healthy subjects through advertisement at the local hospital intranet and at the local university.REC name
Yorkshire & The Humber - South Yorkshire Research Ethics Committee
REC reference
14/YH/1169
Date of REC Opinion
3 Dec 2014
REC opinion
Further Information Favourable Opinion