Linkage of SEATON cohort to GP prescribing data
Research type
Research Study
Full title
Linkage of SEATON cohort to prescribed medication data in the Scottish Prescribing Information System (PIS)
IRAS ID
190289
Contact name
Louise King
Contact email
Sponsor organisation
University of Aberdeen
Duration of Study in the UK
1 years, 11 months, 30 days
Research summary
The Study of Eczema and Asthma To Observe the effects of Nutrition (SEATON study) was designed to relate early dietary exposures to asthma and eczema outcomes in later life (www.abdn.ac.uk/seatonstudy). The babies born to the mothers were followed up at ages 6, 12 and 24 months and 5 and 10 and 15 years. The SEATON cohort was the first study designed to describe associations between early dietary encounters and asthma and eczema outcomes and a number of highly cited publications have already been published.
Routinely acquired fetal ultrasound measurements of participants were also collected as part of the SEATON study and have been used as an index of fetal wellbeing. We have linked fetal measurements and also maternal dietary exposures to asthma and eczema outcomes at ten years. The SEATON cohort has given unique insight into the antenatal origins of asthma and eczema.
Approximately 50% of the original cohort returned their questionnaires as part of the ten year assessment and this is usual for a longitudinal study as contact details and participant enthusiasm for the study are lost. A previous linkage of the SEATON dataset and ISD-held primary care prescribingat the time of the ten year follow up provided follow up data for more than 90% of the SEATON cohort. We have recently completed the 15 year follow up of the cohort and 45% of participants have returned their questionnaires. Here we seeking ethical approval to link ISD-held primary care prescribing data to SEATON participants at 15 years of age. As a secondary/exploratory outcome, we also seek approval to link ISD-held prescribing data to SEATON participants at 5 years of age (i.e. 2002-2004), acknowledging that prescribing data was inconsistently recorded at this time.
REC name
North of Scotland Research Ethics Committee 2
REC reference
15/NS/0120
Date of REC Opinion
13 Nov 2015
REC opinion
Favourable Opinion