LIMITS
Research type
Research Study
Full title
A Randomised Multiple Centre Trial of Conservative versus Liberal Fluid administration for Children Receiving a Kidney Transplant
IRAS ID
354370
Contact name
Wesley Hayes
Contact email
Sponsor organisation
Great Ormond Street Hospital for Children NHS Foundation Trust
Duration of Study in the UK
2 years, 11 months, 31 days
Research summary
Children having a kidney transplant receive fluid by a drip, both during and after the operation. The best amount of fluid for children with a new transplant is not known. Too little fluid may cause delays in the kidney transplant working or blood clots in the transplant. Too much fluid can cause breathing difficulties, swelling, high blood pressure, headaches or fits. These problems are important to patients and take up valuable specialist NHS resources. There is a pressing need to work out the best amount of fluid for children having a kidney transplant.
This research will compare recovery in children having different amounts of fluid after kidney transplant. Children who agree to join the study will be randomised into 2 equal groups. Depending on what group the child is in, they will receive either the usual amount of fluid or a capped amount of fluid tailored to their body size. We will assess children's recovery by the number of days spent at home post transplant. We will work out the impact on health and health service costs from capping fluid compared to usual practice. A total of 140 children from the 10 UK children’s kidney transplant hospitals will take part over 2 years. Participants will continue to have all the usual care that they would otherwise receive. No additional blood samples will be required. We will ask children and parents to report their symptoms and experience of their transplant hospital stay.
This study will help to work out the best amount of fluid for children after kidney transplant. This could speed up children’s recovery, improve their experience of transplant and free up specialist NHS resources. It therefore has the potential to change clinical practice and importantly improve the treatment and outcomes of children receiving kidney transplants in the UK.
REC name
East of England - Cambridge South Research Ethics Committee
REC reference
25/EE/0161
Date of REC Opinion
5 Sep 2025
REC opinion
Further Information Favourable Opinion