Lidocaine levels In DLTBs Study (LID Study)
Research type
Research Study
Full title
Observational study of lidocaine levels in children after airway topicalisation during direct laryngotracheobronchosopy (DLTB).
IRAS ID
156416
Contact name
Robert Walker
Contact email
Sponsor organisation
Central Manchester University Hospitals NHS Foundation Trust
Eudract number
2014-005207-25
Duration of Study in the UK
1 years, 0 months, 1 days
Research summary
When children require an airway examination under general anaesthesia, a local anaesthetic is applied to their airway during the procedure. This is a necessary step, which allows for the examination to take place. The local anaesthetic, which is lidocaine, is sprayed on the airway when the child is anaesthetised. Varying doses, between 3 to 5mg per kg, are currently being used. However, it is unknown what peak plasma lidocaine concentrations are obtained with this technique. We propose to measure plasma lidocaine levels intra-operatively, in order to ascertain peak plasma lidocaine concentrations. This would allow us to ensure the safety of our current dosing regimen, and guide us to any future changes in this. The study is observational, and thus does not involve any change to the routine care delivered to children undergoing this procedure. The single intervention performed during the study is the insertion of a intravenous cannula during general anaesthesia, in order to obtain four blood samples for lidocaine plasma levels.
REC name
North West - Greater Manchester South Research Ethics Committee
REC reference
16/NW/0004
Date of REC Opinion
3 Mar 2016
REC opinion
Further Information Favourable Opinion