Levels of inhaled medicines in asthma and COPD patients, v1
Research type
Research Study
Full title
An investigation of drug concentrations in hair and sweat of subjects with respiratory diseases following the exposure of inhaled chronic respiratory therapies as a future means of assessing treatment related compliance (15-503).
IRAS ID
188346
Contact name
Adeep Puri
Contact email
Sponsor organisation
GSK
Eudract number
2000-123456-78
Duration of Study in the UK
1 years, 0 months, 0 days
Research summary
Many treatments for asthma and chronic obstructive pulmonary disease (COPD) need to be inhaled. Studies have shown that, often, people don’t take inhaled medicines as prescribed by their doctor. If asthmatics or people with COPD don’t take their medication as prescribed, they may increase their risk of having an asthma attack or a severe episode of COPD.
A simple and accurate method for measuring levels of inhaled medicines would help doctors better understand how regularly patients take their medication. We’re doing this study to collect samples of head hair and sweat from people with asthma or COPD, who take an inhaled medicine. We aim to find out if inhaled medicines can be detected in hair and sweat, if the levels of those medicines in hair and sweat vary with dose and if hair samples can be used to monitor patients' use of inhaled medicines. This is not a study of a medicine.
We'll take hair and sweat samples from 200 adults with asthma or COPD who have been taking an inhaled medicine, as prescribed by their doctor, for at least 6 weeks. Participants will make 1 outpatient visit to HMR.
A pharmaceutical company GlaxoSmithKline is funding the study.
The study will take place at 1 centre in London.
REC name
East Midlands - Derby Research Ethics Committee
REC reference
15/EM/0462
Date of REC Opinion
15 Oct 2015
REC opinion
Further Information Favourable Opinion