Level of Adverse pregnancy outcomes in M2 haplotype

• Research type

  Research Study

• Full title

  A feasibility study on testing for M2 gene haplotype to assess its prevalence in high risk couples and association with pregnancy complications

• IRAS ID

  340830

• Contact name

  Shakila Thangaratinam

• Contact email

  s.thangaratinam@liverpool.ac.uk

• Sponsor organisation

  University of Birmingham

• Duration of Study in the UK

  0 years, 8 months, 31 days

• Research summary

  This is a feasibility study looking at testing couples to see whether they are positive for the M2 haplotype. The aims are to:

  - determine the proportion of screened individuals who test positive for the M2 haplotype gene in both males and females
  - assess the willingness of the source population to undergo screening
  - pilot procedures for obtaining informed consent
  - test biosampling methods and laboratory analysis processes

  The study also checks if a simple genetic test for the M2 haplotype, done through saliva or blood samples, is effective in predicting pregnancy outcomes.

  The feasibility study will continue until December 2025.

• REC name

  North West - Preston Research Ethics Committee

• REC reference

  25/NW/0053

• Date of REC Opinion

  6 Mar 2025

• REC opinion

  Unfavourable Opinion