Leeds Multidisciplinary Research Tissue Bank (Renewal 2025)

• Research type

  Research Tissue Bank

• IRAS ID

  352968

• Research summary

  Leeds Multidisciplinary Research Tissue Bank

• REC name

  Yorkshire & The Humber - Leeds East Research Ethics Committee

• REC reference

  25/YH/0022

• Date of REC Opinion

  4 Apr 2025

• REC opinion

  Further Information Favourable Opinion

• Data collection arrangements

  The RTB has had a major focus on renal and urological areas, for example renal cancer, renal transplantation, and bladder cancer but has also recruited patients and stored samples from patients in other areas including ovarian and colorectal cancer, and healthy volunteers have also been recruited. Samples collected include tissue, and fluids such as blood, urine and transplant fluids. Samples are stored at HTA licensed premises of the University of Leeds and Leeds Teaching Hospitals NHS Trust in compliance with the licensing provisions of the Human Tissue Act (2004) and in accordance with joint University/Trust policies. Governance of the Leeds Multidisciplinary RTB is enforced by the Management Committee. All samples are collected and processed by appropriately trained research staff, in dedicated sample processing labs, most of which are run in accordance with Good Clinical Laboratory Practice (GCLP). Informed consent is obtained by members of the healthcare team or appropriately trained staff and comprehensive information is provided to participants. Broad consent is sought to allow use of samples or data in many types of research and across research groups. Relevant clinical data is collected to maximise the use of samples and stored securely in a pseudonymised form.

• Research programme

  The Leeds Multidisciplinary Research Tissue Bank (RTB) supports research conducted in a wide range of disease areas and patient groups. Samples currently in the bank support research in areas including renal, bladder, prostate, colorectal, and ovarian diseases, primarily but not solely cancer, and also transplantation. Samples have been used in a variety of local, national and international research projects and these include studies of many types, for example biomarkers, technical validation of assays, development of therapeutic approaches and understanding mechanisms of disease, with a variety of applications and analyses being undertaken including genomic and proteomic analyses. These are variably funded by a variety of charities, government bodies and industry partners.

• Storage license

  12352

• RTBTitle

  Leeds Multidisciplinary Research Tissue Bank

• Establishment organisation

  Leeds Teaching Hospitals Trust

• Establishment organisation address

  St. James's University Hospital

  Beckett Street

  Leeds

  LS9 7TF