LED-REF

• Research type

  Research Study

• Full title

  Determining reference ranges for a novel Light Emitting Diode (LED) phototest device

• IRAS ID

  335176

• Contact name

  Sally Ibbotson

• Contact email

  s.h.ibbotson@dundee.ac.uk

• Sponsor organisation

  University of Dundee

• ISRCTN Number

  ISRCTN17210709

• Clinicaltrials.gov Identifier

  researchregistry9666, Research Registry

• Duration of Study in the UK

  1 years, 0 months, 0 days

• Research summary

  Dermatologists measure the sensitivity of skin to UV and visible light to help diagnose skin diseases and inform the best possible treatment. Sensitivity is currently tested in photodermatology units by using an irradiation monochromator. This delivers defined wavelengths of light to the skin in a sequence, and any resulting skin reactions are measured. This process can take two to three hours to complete. We have developed a more efficient way of testing sensitivity, by developing a new phototesting device that uses LEDs to deliver different doses to the skin at the same time, so reducing the time taken to do the testing.
  The aim of this study is to collect data from healthy volunteers to show the normal range of skin redness (erythema) reactions to the light delivered by the new phototesting device. Fifty healthy volunteers will be recruited via adverts and SHARE, and will be invited to the Ninewells photobiology unit for screening. If eligible for the study, informed consent will be taken. Consented participants will attend the photobiology unit (day 1) and an area on their back will be exposed to different doses of light. This is painless, and will be followed by assessment of any skin reaction. The next day (day 2) they will return, any skin reaction will be assessed, and they will be exposed to further doses of light. Each visit will last around 3.5 hours. They will return the following day (day 3) for further assessment of any reaction to the light doses. Uncommonly some participants may have further dosing, if they failed to have any reaction to the initial doses. If that is the case, those participants will return the following day (day 4) for final assessment. These data will help inform which doses should be used in the clinic on patients.

• REC name

  HSC REC A

• REC reference

  24/NI/0138

• Date of REC Opinion

  27 Nov 2024

• REC opinion

  Favourable Opinion