LED and FPLD
Research type
Research Study
Full title
Low energy diet and familial partial lipodystrophy
IRAS ID
258670
Contact name
David Savage
Contact email
Sponsor organisation
Cambridge University Hospitals NHS Foundation Trust and University of Cambridge
Clinicaltrials.gov Identifier
Duration of Study in the UK
3 years, 0 months, 1 days
Research summary
The purpose of this study is to evaluate the therapeutic efficacy and metabolic impact of a low energy diet (LED) in people with familial partial lipodystrophy and diabetes. Participants will be provided with a LED (liquid total diet replacement) for 12 weeks, before the introduction of a stepped food transition as was done by Lean et al (Lean et al. 2017) in patients with type 2 diabetes. Metabolic effects will continue to be assessed for 1 year. In order to better understand why this intervention changes insulin sensitivity, we will also collect adipose and muscle tissue samples at baseline and 12 weeks into the intervention in participants willing to have these procedures performed. The original study by Taylor et al (Lim et al. 2011) suggested that insulin resistance was significantly improved by this time point so we anticipate a similar response in our patient cohort. These samples will be used for histological, metabolite, gene expression and protein expression analyses.
REC name
Wales REC 6
REC reference
19/WA/0192
Date of REC Opinion
3 Jul 2019
REC opinion
Further Information Favourable Opinion