LCC-CKD Cohort
Research type
Research Study
Full title
The Leicester City and County Chronic Kidney Disease Cohort
IRAS ID
197145
Contact name
Nigel Brunskill
Contact email
Sponsor organisation
University of Leicester
Duration of Study in the UK
2 years, 4 months, 1 days
Research summary
Chronic kidney disease (CKD) is a long-term condition in which the ability of the kidneys to clean the blood of waste products is reduced. There are many different causes of CKD but the most common are diabetes and high blood pressure. CKD affects approximately 1 in 14 adults in the UK. Every year about 1 in 40 people with CKD have either a heart attack or stroke. This risk is greater in individuals with CKD compared to those without CKD, even after all other factors, such as age and gender, are taken into account. Further, CKD is poorly studied in non-white populations in the UK. Non-white individuals are at even higher risk of the complications of CKD compared to the White population.
This study proposes creating a large group ('cohort') of adult patients with CKD from anonymised GP patient records to study how CKD and its complications develop over the course of time. The cohort will also be used to study the accuracy of a heart attack and stroke prediction aid developed from another similar cohort based in Northamptonshire. Further, as Leicester City and Leicestershire are highly ethnically diverse populations this study will provide new insight into CKD within these groups.
The study will invite GP practices to allow a researcher to analyse their patient records. Anonymised data of individuals with CKD will be extracted from the practice for analysis. The study is unlikely to require more than one visit to each GP practice involved. Where applicable, hospital records of the cohort's patients will also be analysed for reasons for hospital admissions and causes of death.
This proposed study has been generously funded by Kidney Research UK.
REC name
East Midlands - Leicester Central Research Ethics Committee
REC reference
16/EM/0315
Date of REC Opinion
15 Aug 2016
REC opinion
Favourable Opinion