LBM & lung function in adolescents with CF
Research type
Research Study
Full title
Nutritional status and pulmonary and respiratory muscle function in adolescents with cystic fibrosis
IRAS ID
199358
Contact name
Anne Greenough
Contact email
Sponsor organisation
King's College London
Duration of Study in the UK
0 years, 4 months, 3 days
Research summary
In patients with cystic fibrosis (CF) the commonest cause of death is respiratory failure. Respiratory failure can have many causes, however, in patients with CF a major contributor is the impairment of the muscles required for breathing (respiratory muscles). Respiratory muscle impairment can result from poor nutrition. Lung function declines particularly during adolescence whilst body composition also changes at the same time. Thus, we plan to study the relationship of nutrition and body composition to respiratory muscle strength and lung function in children and young people with CF aged between 12-18 years. The body mass index (BMI) is used in the clinical setting to measure nutritional status in CF. At King’s College Hospital (KCH) we have portable devices to assess both respiratory muscle function and lung function. We will use a Bioelectrical Impedance Analysis (BIA) device to assess body composition, including BMI and lean body mass (LBM). We aim to assess whether measurements of LBM impairment may better relate to poor lung function compared to BMI. Finally, we aim to examine whether lung and respiratory muscle function correlates with exercise tolerance.
REC name
East Midlands - Nottingham 2 Research Ethics Committee
REC reference
16/EM/0174
Date of REC Opinion
16 May 2016
REC opinion
Further Information Favourable Opinion