LapHSI
Research type
Research Study
Full title
Intraoperative hyperspectral imaging for laparoscopic surgery (LapHSI): a multicentre clinical feasibility study
IRAS ID
321001
Contact name
Jonathan Shapey
Contact email
Sponsor organisation
Research and Innovation, King's College London
Duration of Study in the UK
0 years, 6 months, 31 days
Research summary
The study aims to evaluate the clinical feasibility, safety, and utility of the HyperSnap Surgical System (HSS1), a hyperspectral camera designed to provide real-time visualisation and monitoring of tissue oxygenation (StO2) during laparoscopic abdominal surgeries. Additionally, it will assess how incorporating this technology into the surgical workflow affects clinical decision-making and outcomes, particularly in bowel resection procedures.
Bowel (colorectal) cancer is the third most common cancer worldwide, with its incidence projected to increase by 60% between 2015 and 2030. The standard treatment for colorectal cancer is surgical resection, where the affected bowel is removed, and the healthy sections are joined through an anastomosis. Ensuring proper tissue oxygenation during anastomosis is critical, as inadequate oxygenation can lead to complications such as anastomotic leakage. Gallstones affect approximately 15% of the UK population, with 20% of those cases requiring surgery. A significant complication of gallbladder removal (cholecystectomy) is bile duct injury (BDI), which occurs in 0.4–1.5% of cases and can have serious consequences.
The study will focus on enhancing intraoperative imaging using the HSS1 system during colorectal cancer resections and cholecystectomy surgeries. Hyperspectral Imaging (HSI) offers highly detailed visualisations of tissues, potentially reducing complications and improving surgical outcomes. HSI works by analysing light scattering across sixteen spectral channels, revealing internal structures that are invisible to the human eye. The data can also be converted into standard Red/Green/Blue (RGB) images, providing familiar laparoscopic visuals. During bowel resections, real-time StO2 mapping will assist surgeons in decision-making, with final decisions left entirely to the discretion of the primary surgeon, based on their expertise and experience.
The study recruits adult patients aged 18 and over who are able to provide informed consent and are undergoing either laparoscopic bowel resection for colorectal cancer or laparoscopic cholecystectomy.
The study will take place over six months at King’s College Hospital, Leeds Teaching Hospitals, and St Thomas' Hospital, enrolling a total of 40 patients—10 for cholecystectomy and 30 for bowel resections. Patients will be followed for approximately three months post-surgery with standard care and follow-up assessments. Surgeons will also complete questionnaires evaluating the usability and effectiveness of the HSS1 system.
REC name
London - Dulwich Research Ethics Committee
REC reference
24/LO/0896
Date of REC Opinion
23 Jan 2025
REC opinion
Further Information Favourable Opinion