LaCeS feasibility
Research type
Research Study
Full title
LaCeS Feasibility: Laparoscopic versus Open Colorectal Surgery in the Acute setting
IRAS ID
186054
Contact email
Sponsor organisation
Leeds Teaching Hospitals NHS Trust
ISRCTN Number
ISRCTN15681041
Duration of Study in the UK
2 years, 4 months, 31 days
Research summary
Emergency general surgery is one of the commonest reasons for admission to hospital. There is a wide range of problems which can lead to emergency admission and diseases that affect the large bowel (e.g. diverticular disease and cancer) make up a third of diseases that present as an emergency.\n\nThere are two different types of operation which can be used in surgery; keyhole and open surgery (where a bigger cut is made). Currently, keyhole surgery is used in planned (elective) surgery involving the large bowel, but in the emergency setting surgeons opt for open surgery more often than keyhole surgery. Surgeons speculate that using keyhole surgery in the emergency setting may result in shorter recovery time, reduced pain and shorter length of stay compared to open surgery, however we are not sure, as the current evidence is not strong enough to draw any firm conclusions.\n\nStudy Design:\nThe trial will run in NHS hospitals within acute general surgery services. Patients requiring emergency surgery on the large bowel will be invited to participate in a trial in which half will be treated with open surgery and half with keyhole surgery. Treatment will not be chosen by the patient or doctor but through a process called randomisation, patients will be blinded for 7 days. This study will help determine the safety of keyhole surgery in the emergency setting. The study will also determine the willingness of patients and surgeons to participate in such a study and enable us to finalise the design before embarking on a larger trial. In this initial study we will collect information about why patients choose to take part or not and ask patients and clinicians their opinion about the design of the trial. Participants will be followed up for up to 6 or 12 months.\n
REC name
Yorkshire & The Humber - Bradford Leeds Research Ethics Committee
REC reference
15/YH/0542
Date of REC Opinion
1 Feb 2016
REC opinion
Further Information Favourable Opinion