Labelling and imaging of leukocyte subpopulations 1.0
Research type
Research Study
Full title
Labelling and imaging of leukocyte subpopulations using PET, SPECT, MRI and optical fluorescence
IRAS ID
222704
Contact name
Ferdia Gallagher
Contact email
Sponsor organisation
Cambridge University Hospitals NHS Foundation Trust
Duration of Study in the UK
3 years, 8 months, 4 days
Research summary
Research Summary:
Tumours are often surrounded and invaded by bone marrow derived cells. Imaging the infiltration of such immune cells into tumours may therefore be an attractive means of detecting tumours or of tracking the response to anticancer therapy. These immune cells can be detected noninvasively by positron emission tomography (PET), single-photon emission computed tomography (SPECT), magnetic resonance imaging (MRI) or other optical imaging modalities like fluorescence. This study will investigate the in vitro labelling of leukocytes and subsequent imaging by means of different modalities that will help in the establishment of future immuno-PET applications. Human blood samples donated by healthy volunteers and leukocytes cones from anonymous healthy donors obtained from the NHSBT will be used as cell samples that are labelled in vitro. The blood samples will be used immediately after they are obtained and will not be stored before and after labelling experiments and the respective analysis. The analysis post-labelling does not include specific genetic blood tests or any other intervention. Only functional, biochemical and/or haematological analysis may be performed on the blood sample after labelling before the sample will be appropriately disposed.
Lay Summary of Results:
This study has been inactive since Sep 2022. I can confirm that no volunteers were ever recruited for this study. During the project, plans and logistics changed, and the PhD student did not require blood from volunteers as alternative cells were obtained from collaborators. While the study remained open for some time ‘just in case’, it is now closed. There is no data to report or include in this study.
REC name
North East - York Research Ethics Committee
REC reference
17/NE/0168
Date of REC Opinion
18 May 2017
REC opinion
Favourable Opinion