KTOP
Research type
Research Study
Full title
Kidney Transplantation in Older People (KTOP): impact of frailty on outcomes
IRAS ID
264417
Contact name
Edwina A Brown
Contact email
Sponsor organisation
Imperial College London and Imperial College Healthcare NHS Trust
Clinicaltrials.gov Identifier
WMIH_P77772, Imperial College - Oracle
Duration of Study in the UK
3 years, 0 months, 1 days
Research summary
Transplantation for older patients remains a challenge. With increasing numbers of older patients developing end-stage kidney disease (ESKD), there is an expectation from many that transplantation should be offered. Frailty and cognitive impairment are common in this patient group but often under-recognised. Little is known about the impact of frailty and its components, particularly cognitive impairment, on transplant outcomes, patient experiences, quality of life and adherence to complex immunosuppression drug regimes. Central to the proposed mixed methods research is a prospective observational study enrolling patients >60 years old from the transplant wait-list who may already be frail, or develop frailty during the study duration. Quality of life will be assessed using questionnaires at study visits on wait-list and post-transplant alongside recording clinical outcomes. Adherence to mmunosuppression will be assessed at post-transplant visits. Impact of age and frailty induced inflammatory state and immunosenescence will be assessed by measuring various biomarkers at entry to the study and correlating them with subsequent patient\nand transplant outcomes.
REC name
Yorkshire & The Humber - Leeds West Research Ethics Committee
REC reference
19/YH/0287
Date of REC Opinion
6 Sep 2019
REC opinion
Further Information Favourable Opinion