Kids4LIFe
Research type
Research Study
Full title
Assessing Kids for Liver Inflammation and Fibrosis using non-invasive MRI
IRAS ID
201128
Contact name
Kate Groves
Contact email
Sponsor organisation
Perspectum Diagnostics Ltd
Duration of Study in the UK
2 years, 0 months, 1 days
Research summary
Paediatric liver diseases are 'silent killers' as clinical symptoms only surface at late stages of the disease. 1 in 5 children in Europe suffer from fatty liver disease, which carries several health risks. We have demonstrated that multiparametric MR imaging can accurately and non-invasively assess the health of liver tissue in adults, but assessment of children's livers is more complex as a) a child’s liver is smaller so spatial resolution is more limited, b) children (and their livers) grow substantially from 6 to 18 and c) the demands on children’s livers change with their age. Therefore, in this study we want to find out whether the same technique can be used to chart the development of the liver throughout childhood and adolescence. By creating an atlas of healthy children's livers and biliary ducts we will be able to use these to compare with images from children with suspected liver disease in the future and hopefully enable earlier diagnosis of liver disease.
REC name
South Central - Oxford C Research Ethics Committee
REC reference
16/SC/0621
Date of REC Opinion
23 Dec 2016
REC opinion
Further Information Favourable Opinion