KID

• Research type

  Research Study

• Full title

  Preventing kidney injury using carbon dioxide as contrast medium in patients with Peripheral Arterial Disease (PAD) and Chronic Kidney Disease (CKD) having arterial intervention (The KID TRIAL)

• IRAS ID

  340062

• Contact name

  Cat Taylor

• Contact email

  rgosponsor@le.ac.uk

• Sponsor organisation

  University of Leicester

• ISRCTN Number

  ISRCTN23564393

• Duration of Study in the UK

  1 years, 9 months, 31 days

• Research summary

  This research will test whether using carbon dioxide (C02) contrast for surgery to open blocked leg arteries can prevent kidney problems. One in five people suffer with narrowings or blockages in their leg arteries. This is called peripheral arterial disease. It leads to poor leg circulation, which can cause leg gangrene or infection. Sometimes this may even lead to amputation. To prevent this from happening, the affected arteries have to be opened. This is usually done using x rays and balloons to stretch the arteries open. These procedures are the most common artery surgeries in the NHS. To be able to do these procedures, doctors use a dye injected in the artery. This dye can affect kidney function. Instead of the usual dye that causes kidney problems, carbon dioxide can be used. Carbon dioxide does not cause damage to the kidneys. No previous research, however, has tested whether using carbon dioxide does indeed protect the kidneys in these specific procedures.
  This research will take place in at least six NHS hospitals. People with peripheral arterial disease who are having a procedure to open their arteries will be asked to take part. They will be randomly chosen to have the procedure with or without carbon dioxide. We will then do a blood test on the 2nd, 30th and 90th day after the procedure, to compare kidney function between the two groups (with/without carbon dioxide). We will also compare the volume of artery dye used. We will also do some qualitative research into how the hospital staff performing the intervention feel, as well as how participants of the study found the procedure with carbon dioxide.

• REC name

  Wales REC 7

• REC reference

  24/WA/0332

• Date of REC Opinion

  5 Nov 2024

• REC opinion

  Further Information Favourable Opinion