KD Coagulation Research Plasma Bank (2019 Renewal application)
Research type
Research Tissue Bank
IRAS ID
272820
Research summary
The Katharine Dormandy Coagulation Research Plasma Bank
REC name
Yorkshire & The Humber - Sheffield Research Ethics Committee
REC reference
20/YH/0051
Date of REC Opinion
22 May 2020
REC opinion
Further Information Favourable Opinion
Data collection arrangements
When a patient consents to donate a sample to the plasma bank, following adequate discussion and time to read the information sheet, blood will be taken at the same time as other routine tests, whenever possible. Up to 40 mls of blood (equivalent to 6 teaspoons) will be taken. Serial testing may be done but in this instance no more than 100mL in 24 hours will be taken.
Healthy volunteers will give a sample of up to 40mL. Serial testing may be done but sampling timepoints must be at least 24 hours apart.
Volunteers and patients may consent to provide a single sample of 150mL. This will primarily be used for quality assurance exercises and spiking experiments to evaluate efficacy.
The sample may be used immediately, whilst some of the plasma may be frozen for future use and stored in the research laboratory. With the patients’ consent, we also isolate and store DNA that contains the information necessary for the development and functioning of cells and tissues.
The samples will be kept in freezers in the Katharine Dormandy Haemophilia and Thrombosis Unit research laboratory and will only be handled by employees of the centre (either research or laboratory staff).
Research programme
The Katharine Dormandy Coagulation Research Plasma Bank is a collection of blood samples that can be used in research to better understand blood coagulation or clotting. Instead of collecting samples from patients for individual projects, the plasma bank enables us to create a ‘library’ of samples from patients with different types of problems with their blood clotting. The Haemophilia Centre at the Royal Free Hospital is a centre of excellence and sees large numbers of patients with both inherited and acquired coagulation disorders affecting the process by which blood forms a clot. The plasma bank allows ongoing research into the underlying causes of these disorders, tests to allow the prediction of the severity of the disorder, tailoring treatment to individual patients and validation of new laboratory tests. All projects will have been approved by a panel of experts. Results of the research performed will be presented at national and international conferences and submitted for publication in appropriate journals. The aim of all research is to be able to provide the best care possible to patients with clotting disorders.
Storage license
n/a
RTBTitle
The Katharine Dormandy Coagulation Research Plasma Bank
Establishment organisation
Royal Free London NHS Foundation Trust
Establishment organisation address
KD Haemophilia Centre and Thrombosis Unit
Pond Street
London
NW3 2QG