KD Coagulation Research Plasma Bank (2014 Renewal application)

• Research type

  Research Tissue Bank

• IRAS ID

  154396

• Research summary

  The Katharine Dormandy Coagulation Research Plasma Bank

• REC name

  Yorkshire & The Humber - Sheffield Research Ethics Committee

• REC reference

  14/YH/1272

• Date of REC Opinion

  30 Jan 2015

• REC opinion

  Further Information Favourable Opinion

• Data collection arrangements

  Patients will be approached by a member of the clinical team and asked whether they will consider donating to the plasma bank. When a patient consents to donate a sample to the plasma bank, following adequate discussion and time to read the information sheet, the blood will be taken at the same time as other routine tests, whenever possible. 30-40 mls of blood (equivalent to 4-6 teaspoons) will be taken, of which some may be used immediately, whilst some of the plasma (the liquid part of the blood that contains clotting factors) may be frozen for future use and stored in the research laboratory. With the patients’ consent, we also isolate and store DNA that contains the information necessary for the development and functioning of cells and tissues. In addition data related to the samples and the research project will be extracted from the notes by members of the direct health care team or research team. All information will be kept strictly confidential.
  The samples will be kept in freezers in the Katharine Dormandy Haemophilia and Thrombosis Unit research laboratory and will only be handled by employees of the centre (either research or laboratory staff). They will be allocated alphanumeric codes to ensure confidentiality, but these codes will be linked on the laboratory computer systems to patients hospital numbers and access is restricted to designated members of the staff.

• Research programme

  The Katharine Dormandy Coagulation Research Plasma Bank is a collection of blood samples that can be used in research to better understand blood coagulation or clotting. Instead of collecting samples from patients for individual projects, the plasma bank enables us to create a ‘library’ of samples from patients with different types of problems with their blood clotting. The Haemophilia Centre at the Royal Free Hospital is a centre of excellence and sees large numbers of patients with both inherited and acquired coagulation disorders affecting the process by which blood forms a clot. The plasma bank allows on-going research into the underlying causes of these disorders, tests to allow the prediction of the severity of the disorder, tailoring treatment to individual patients and validation of new laboratory tests. All projects will have been approved by a panel of experts. Results of the research performed will be presented at national and international conferences and submitted for publication in appropriate journals. The aim of all research is to be able to provide the best care possible to patients with clotting disorders.

• RTBTitle

  The Katharine Dormandy Coagulation Research Plasma Bank

• Establishment organisation

  NHS

• Establishment organisation address

  ROYAL FREE NHS FOUNDATION TRUST

  ROYAL FREE HOSPITAL

  POND STREET

  NW3 2QG