KCL HI-RTB

• Research type

  Research Tissue Bank

• IRAS ID

  244510

• Research summary

  KCL Human Islet Research Tissue Bank

• REC name

  South West - Central Bristol Research Ethics Committee

• REC reference

  20/SW/0074

• Date of REC Opinion

  4 May 2020

• REC opinion

  Favourable Opinion

• Data collection arrangements

  Human pancreases will be collected from patients in accordance with the patient consent form and patient information sheet.Islet samples will be processed, stored and disposed in accordance with all applicable legal and regulatory requirements, including the Human Tissue Act 2004 and any amendments thereafter. During experiments, isolated islets will be maintained in culture for up to 14 days post-isolation. Long-term, human islet material will be stored for future experimental use in preserved form (as fixed whole-islets) and processed form (as islet RNA, DNA and protein) in the RTB until required. Storage of material long-term will be in fridges, freezers or locked cabinets within the Department of Diabetes Research Laboratories at the Guy’s campus of KCL. Samples will be coded. Information linked to the code will include a record of the donor number, islet preparation number, associated donor data (age, sex, BMI, diabetic status) and the project the islets were used for, as well as associated experimental data. No personal, identifiable donor information will be available to the RTB or linked to the codes. Patient consent and information sheets are attached to this application

• Research programme

  The human islets donated for this RTB will be utilised to generate data which will help us to (1) understand the underlying mechanisms of beta-cell failure in type 1 and type 2 diabetes. This information will in turn be used to; (2) identify and develop novel therapeutic approaches for treatment of type 1 and type 2 diabetes, as well as; (3) develop methods for improved survival and function of transplanted islets. These aims represent the three major research themes of researchers in the Department of Diabetes at King’s College London, who will have access to tissue stored in this biobank. Therefore, the establishment of the biobank has the potential to provide huge benefits to people with diabetes, in terms of providing more effective treatment options, which will allow better blood glucose control and reduced onset of life-threatening diabetic complications. This would have major benefits for patients as well as for society as a whole via reduced health care costs and wider economic benefits

• Storage license

  12521

• RTBTitle

  KCL Human Islet Research Tissue Bank

• Establishment organisation

  King's College London

• Establishment organisation address

  Strand, London

  WC2R 2LS