JEDI-2
Research type
Research Study
Full title
Characterisation of endothelial cells in multiple inflammatory pathologies
IRAS ID
320251
Contact name
Ben Creagh-Brown
Contact email
Sponsor organisation
Royal Surrey NHS Trust
Duration of Study in the UK
1 years, 11 months, 30 days
Research summary
The immune system is a complex series of cells and molecules that interacts with every tissue and system in the body, including the endothelial cells that line blood vessels. When the body is exposed to infection or trauma, inflammation can start to damage the body. When immune cells damage endothelial cells, changes happen to the instructional molecules (mRNA) which alter function. This change in function allows fluid from your blood can leak into the surrounding tissues, blood pressure drops and blood clotting. This leads to organ damage and death. This study aims to capture endothelial cells from patients exposed to trauma (surgery) or infection (sepsis) with the intention to study the change in mRNA.
During a previous study, our research team tested the feasibility of using a technique known as endovascular biopsy to safely isolate these cells from patients. The procedure involves inserting a cannula into a forearm vein of a patient, then gently passing a small guidewire into the vessel to isolate endothelial cells. These cells are then isolated in a laboratory. For this study we plan to use this technique again to isolate endothelial cells while taking a blood sample at the same time.
All participants involved in this study will be a patient at Royal Surrey Hospital. They will either be undergoing major abdominal surgery and requiring recovery in Intensive Care or admitted to Intensive Care due to severe illness. Patient involvement in the study will last 3 days post enrolment and will not affect any other aspects of their care.REC name
South Central - Hampshire A Research Ethics Committee
REC reference
24/SC/0058
Date of REC Opinion
15 Apr 2024
REC opinion
Further Information Favourable Opinion