iTACTIC v1.0
Research type
Research Study
Full title
Implementing Treatment Algorithms for the Correction of Trauma Induced Coagulopathy
IRAS ID
185794
Contact name
Karim Brohi
Contact email
Sponsor organisation
Queen Mary University of London
Clinicaltrials.gov Identifier
Duration of Study in the UK
2 years, 0 months, 1 days
Research summary
Trauma is the most frequent cause of death in persons aged under 40, with half of these deaths resulting from uncontrolled bleeding. 1 in 4 of all severely injured and shocked patients develop a clotting abnormality termed Trauma Induced Coagulopathy (TIC) within minutes of injury, which causes blood to continue being lost from the body faster than it can be stemmed. Many more injured patients will go on to develop different types of coagulopathy at different times during the course of their treatment, either as a result of their body’s on-going response to trauma or as a consequence of their clinical care. Ultimately coagulopathic patients have increased blood transfusion requirements and suffer more adverse outcomes (e.g. multi-organ failure). \n\nCurrent management of coagulopathic, haemorrhaging trauma patients comprises the unguided transfusion of large volumes of red blood cells and clotting product supplements. Without rapidly available and validated diagnostics, products are delivered empirically to patients blind to the type and severity of TIC they may have - or indeed even if they do not have TIC. This multi-centre, prospective, randomized controlled study will compare outcomes of viscoelastic haemostatic assay (VHA)-guided resuscitation versus conventional resuscitation support in haemorrhaging trauma patients. The hypothesis is that goal-directed haemostatic resuscitation of coagulopathic bleeding trauma patients will yield improved outcomes and reduced blood product demand, compared to empiric massive transfusion therapy.
REC name
London - Harrow Research Ethics Committee
REC reference
16/LO/0004
Date of REC Opinion
4 Apr 2016
REC opinion
Further Information Favourable Opinion